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Excessive oxidative damage may adversely affect healthy tissues, requiring a thorough comprehension of the therapeutic threshold: identifying the ideal quantity of lipid peroxidation for successful cancer treatment while reducing collateral damage [11]

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After RSL3 treatment, the viability of A549 and HT1080 cells was significantly reduced by the combination of DHODH deletion and LDHB silencing compared to both single alterations and could be completely rescued by FER1 supplementation (Fig

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