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San Luis Obispo, San Francisco, Lodi, and Sacramento testify to their presumption

Since the activity of CYP1A2 varies greatly from individual to individual, literature evidenced that there are different influential factors, such as genetics, coffee consumption, oral contraceptive use and smoking, even if the mechanisms are complex and not completely clear [21]

That, combined with the fact that California recently raised its smoking age to 21, should have an impact on total consumption

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It actually changes the chemical composition of the tobacco itself, which results in a different flavor profile so you might have the exact same components, the exact same ratios between a ribbon-cut tobacco and a plug-cut tobacco, but they're gonna be slightly different in flavor profile, generally speaking

This could be because of behavioural differences in younger children, such as placing hands and other objects in the mouth more often, or in how younger children tend to absorb more lead than adolescents and adults