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A compelling real-world illustration involved an adolescent athlete with EDS: a 15-year-old baseball pitcher with hypermobile EDS and a painful shoulder injury (supraspinatus tear)

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Elevated expression of liver de novo serine synthesis pathway enzymes, phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase 1 (PSAT1), is among the most reproducible responses to dietary SAAR, making their increase a marker of a successful dietary intervention (2

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