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Although melatonin treatment was associated with reduced GLUT1 expression ( Figure 5J ), this did not translate into a functional deficit in glucose uptake, as melatonin-treated cells displayed comparable 2-NBDG uptake to controls ( Figure 5K )

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Reported tolerability in the available human observational work is high: no consistent pattern of adverse effects has been published, although the absence of placebo-controlled trials means subtle effects cannot be excluded

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