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"Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial." Nature Medicine , 29(11), 2909-2918

However, the anti-inflammatory effects of GLP-1 agonists appear to provide benefit beyond what weight loss alone would explain

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No placebo group

A holistic approach that includes a balanced diet, regular physical activity, and lifestyle modifications remains crucial for achieving and sustaining healthy weight loss

Tirzepatide as a Weight Loss Agent Through its activation of GIP receptors in fat cells, tirzepatide works to decrease adipose inflammation while increasing adiponectin, thus reducing fat cell differentiation and increasing energy expenditure, leading to weight loss [11]