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Vascular Effects Vascular effects include: Angiogenesis Promotion Through VEGF and bFGF expression at 1 nM concentration Improved Blood Vessel Integrity Through collagen and elastin synthesis in vessel walls SPARC Protein Release Released during injury stimulates vessel growth and repair Enhanced Microcirculation Improved blood flow to peripheral tissues Anticoagulation Properties Demonstrated effects on blood clotting factors Restored Blood Flow To damaged tissues enhancing healing capacity Injectable Dosing Protocols and Administration Injectable GHK-Cu protocols typically use carefully calibrated dosing based on decades of research and clinical experience

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8, 52, 53 Both mechanisms of action for BSO could be clinically important because previous studies have demonstrated that increased DNA crosslink/monoadducts and slow repair of DNA damage in L-PAM-treated patients is correlated to longer progression-free survival and improved outcome of treatment