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The OASIS program evaluated oral semaglutide 50 mg daily in adults with obesity and reported weight loss broadly comparable to the injectable 2.4 mg dose in the region of 15% of body weight
Two additional GLP-1s, Wegovy and Zepbound TM , have been approved within the last two years
More serious but less common side effects to watch for at this dose include acute pancreatitis (symptoms: severe abdominal pain radiating to the back, nausea, vomiting), gallbladder problems (symptoms: sudden pain in the upper right abdomen, fever, jaundice), and significant hypoglycemia if combined with certain diabetes medications
Heyman et al
How much protein do I really need during GLP-1 therapy
Sublingual semaglutide is $249 per month with a $179 tier
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