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Therefore, particular caution should be taken to avoid prescription of high nicotine concentration liquids and open systems

Withdrawal is characterized by negative affective states (irritability, anxiety, depression, anhedonia) and craving, partly mediated by dopamine deficits and activation of stress pathways involving corticotropin releasing factor

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a 24-h sustained-release transdermal patch, and immediate-release gum, lozenge, inhaler, and oral spray) are available without a prescription because they pose a minimal risk even with long-term use [5]

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