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Side effects Women facing persistent nausea, fatigue, or GI discomfort that with dose adjustments usually feel like trying a different medication

Kraniak JM, Chalasani A, Wallace MR, Mattingly RR

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The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group