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Regarding CAT mRNA expression, an increase in mRNA levels was described in adults with simple steatosis (Aljomah et al

Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research

Thus the rapid reimport hypothesis explains both sets of data

The results highlight nitrosative redox chemistry as a potentially physiologically relevant pathway for dsNNTTR formation and support a model in which controlled thiol modification, rather than generalized oxidative stress, may contribute to pathological TTR crosslinking in vivo

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