REDEFINE 1 showed CagriSema was superior to semaglutide alone, cagrilintide alone, and placebo
The GSA family in 2025: a broadened sharing platform for multi-omics and multimodal data
These effects collectively lower both fasting and postmeal glucose levels, with an average 24h glucose reduction of about 1 mmol/L [56, 57]
In the SURMOUNT-1 clinical trial, participants taking the highest dose of tirzepatide (15 mg) lost an average of 22.5% of their body weight over 72 weeks
Furthermore, to explore the long-term anti-degradative effect of liraglutide, IL-1-stimulated chondrocytes were cultured with 2 ng/mL of IL-1 and 50 nM of liraglutide for 72 h
Moreover, a recent study demonstrated that ALDH2 could alleviate MIAinduced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression [88]