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Mechanistically, TB-500s parent peptide (T4) drives endothelial cell migration, tubule formation, and angiogenesis, processes essential for granulation tissue and perfusion during healing

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doi: 10.1186/s12902-022-01143-y 242 LiuWLiSLouXLiDWangFZhangZ

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Necroptosis is a form of regulated necrosis mediated by death receptors and executed through the induction of receptor-interacting protein kinase 1 and 3 (RIPK1-RIPK3) necrosome, phosphorylation and oligomerization of mixed lineage kinase domain-like protein (MLKL), and plasma membrane disruption 4,5,6

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