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In Europe, a liquid formulation of dronabinol (named BX 1), produced by Bionorica SE (D), began a Phase III trial to evaluate the efficacy and safety as adjuvant therapy to first-line standard chemotherapy in patients with metastatic pancreatic cancer ( n = 140) for the improvement of chemotherapy- and tumour-related symptoms (EudraCT2019-000616-28

Similarly, ovarian oxidative stress model mice exhibit inhibition of the Nrf2/HO-1/GPX4 pathway (Niu et al., 2023), suggesting that GPX4 deficiency-induced ferroptosis may contribute to reduced ovarian reserve

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