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The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations

Cyanocobalamin is a synthetic form of vitamin B12 found only in supplements, while Methylcobalamin is a naturally occurring form that you can get through either food sources or supplements

You should expect that all the time