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Additional information Supplementary Information accompanies the paper on the Translational Psychiatry website Supplementary information Rights and permissions This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License

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Oral numbing agents, such as Orajel and Anbesol , are medications that can be applied directly (topically) to the surface of the mouth and gums (oral mucosa) to relieve pain from toothaches, canker sores, and braces