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Eur J Integr Med 39:101213

This degradation converts CGN with Mw = 200,000 800,000 Da

Additionally, berberine has been shown to inhibit the phosphorylation of forkhead box O1 (FoxO1) and Akt in rats with bile duct ligation-induced liver fibrosis and in HSCs, further supporting its potential as a treatment for liver fibrosis [173]

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At the same time, there was an increasing focus on the potentially harmful effects of lipid peroxidation (Heath and Packer 1968), growing awareness that optimal activities of photosynthetic enzymes required a highly reducing environment (Wolosiuk and Buchanan 1977