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E-cigarette companies have been accused of deliberately targeting young adults and adolescents via tactics such as leveraging social media, sponsorship of festivals and music events, and introduction of flavors that appeal to youth

Acknowledgements The authors thank Cambustion Ltd

CTBAT is a joint venture between China Tobacco and BAT Plc formed in 2013 that is the owner of the former BAT brand State Express 555 worldwide and of Double Happiness in a number of jurisdictions outside the Mainland of China

It's a full-bodied taste made with earth-friendly, whole-leaf tobacco and water

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At the higher concentration, 36 milligrams per milliliter of nicotine, the e-cigarette aerosol doubled the risk of atherosclerosis