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For unopened pens, consult your pharmacist or GP as UK guidance does not specify grace periods for unrefrigerated storage

In addition, rapid weight loss associated with these medications can affect skin elasticity and hydration, which may be misinterpreted as inflammatory reactions

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The medication slows down the amount of sugar released into the bloodstream

it does not bring about weight-loss or fat-redistribution, nor does it reduce hunger or induce a feeling of well-being. It further concluded that the effect of the Simeons therapy can be attributed to a diet of 500 kcal, but that the HCG has no specific effect