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The N-methylhistamine is further broken down with the MAO-B enzyme, forming N -methylimidazole acetaldehyde.[ref] Histamine (from body cells) [HNMT enzyme] N-methylhistamine [MAO-B enzyme] N-methylimidazole acetaldehyde Note that the HNMT enzyme (histamine N-methyltransferase) facilitates the transfer of a methyl group in the breakdown of histamine through this pathway

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A key advancement in addressing these mechanisms is the shift from a neuron-centric to a holistic view that encompasses the critical role of glial cells, a perspective that informs the diverse therapeutic toolkit explored in the following sections

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15(8): 66370 Candiotti K, Singla N, Wininger S, et al

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