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Description

& Park, J

Dopamine signaling in the mesolimbic system becomes dysregulated, making natural rewards feel muted while drug-related cues gain overwhelming salience

Outcome: After 8 months, retinopathy severity unchanged (stable mild NPDR) versus historic 6-12 month worsening pattern

2,3 Despite being developed to treat hyperglycemia in T2D, GLP-1RAs at high doses have clinically significant effects on body weight in people with obesity