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Discussion While GLP-1 RAs are powerful anti-obesity medications (AOMs), they do raise some serious concerns most notably, up to 40% of the profound weight loss induced by these agents can be due to loss of lean mass 35 and prior studies have shown that a significant portion of this lean mass is muscle 3335

People who have noticed increased thirst on tirzepatide should listen to that signal rather than ignoring it

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Not everyone who meets the BMI criteria will be a good candidate

The goal of each stage is not to rush toward the highest dose, but to find the lowest effective dose a person can tolerate long term