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This tells the pituitary to release a growth hormone pulse, which then drives downstream effects: IGF-1 production, muscle protein synthesis, fat mobilisation, and tissue repair
The chart below from Weight regain and cardiometabolic effects after withdrawal of semaglutide also show a rapid regain after stopping the drugs
doi:10.1111/j.1365-2265.1992.tb02267.x Foley TP Jr
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