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Several hypothesis were developed to explain MDD pathogenesis pathogenic including (i) the hypothalamicpituitaryadrenal (HPA) axis dysfunction hypothesis, (ii) the monoamine hypothesis, (iii) the inflammatory hypothesis, (iv) the genetic and epigenetic anomaly hypothesis, (v) the structural and functional brain remodeling hypothesis, and (vi) the social psychological hypothesis 3,15,16 (Fig

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Chen TK, Knicely DH, Grams ME

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van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gmez-Gallego F, et al