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Unexpectedly, tumor burden was significantly reduced in mice with NOS2-deficient bone marrow chimers compared to the wild-type mice, suggesting that even though the number of M2 macrophages in iNOS-deficient TME is not affected, the immunosuppressive function of M2 macrophages may change

Next-generation oral medications in development aim to match injectable efficacy, which would dramatically expand the patient population willing to consider treatment

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Why this matters: early pregnancy can begin before a missed period