First, 1,25(OH) 2 D 3 exerts immunomodulatory effects by enhancing antimicrobial protein expression and activating the nucleotide-binding oligomerization domain containing 2 (NOD2)-HBD2 signaling pathway ( 2 D 3 induces NOD2 expression, which activates NF-B signaling to induce HBD2 production ( 3 deficiency and CD genetic susceptibility, thereby regulating immune cells and inflammatory cascades ( 2 D 3 strengthens intestinal epithelial barrier function by inducing tight junction protein expression, including zonula occludens-1 (ZO-1) and claudin-1 (142)
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HLA-B27 and psoriatic disease: a modern view of an old relationship
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