A simple in-office examination, sometimes with a dermatoscope, is usually enough to confirm whether the spot is a benign macule or requires further investigation
These risks may be amplified in older patients due to underlying immune dysregulation associated with inflammaging. Implementing rigorous safety protocols, adapted from oncology, such as careful dose escalation and monitoring for autoantibodies, will be essential to ensure patient safety 118,119
Furthermore, concurrent use with cannabidiol can lead to a buildup of a Clobazam byproduct, leading to excess sedation
PMID: 10699157 Stohs SJ, Bagchi D
NAD+ levels in human skin decline with age, and this decline affects multiple repair mechanisms simultaneously: DNA repair capacity (through PARP enzyme activity), mitochondrial energy production in skin cells, autophagy of damaged proteins, including glycated collagen, and the sirtuin-mediated preservation of collagen integrity
doi:10.1111/dom.13339 8