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Patients tend to experience the best results once they reach their maximum maintenance dose, though some patients find success at lower doses

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[17] [18] Glibenclamide may occasionally be considered under specialist supervision when other options are unsuitable, with careful monitoring of the infant for signs of hypoglycaemia (poor feeding, jitteriness, unusual sleepiness)

Much research has studied the role of RES in modulating Nrf2 in PD models, which recognise oxidants and modulate antioxidant defence

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