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H 2 S production may be involved in vascular smooth muscle cell relaxation through regulating the opening/closing of potassium channels and/or enhancing NO-dependent signaling pathway (reviewed in 53)

PTPN22 increases the risk of vitiligo owing to its effect on protein tyrosine phosphatase, which plays a key role in signal transduction and controls the activity of the T-cell immune system

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The Atgsnor1 mutant for the enzyme GSNO reductase has compromised resistance to both virulent and avirulent pathogens (Feechan et al., 2005)