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The reduction in currents generated by ALLO at 42 GABA A R is dependent upon the presence of arginine 353 in the intracellular loop of 4, where it may serve as a chloride modulatory site (345)

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doi: 10.1530/raf-23-0024

This process is essential for cognitive resilience during aging , and it explains why researchers interested in anti-aging strategies pay such close attention to BDNF levels