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Human evidence and its limits Controlled human feeding studies show increases in TMA or TMAO after high intake of L-carnitine or choline in many subjects

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Mitochondrial dysfunction Mitochondria are the core organelles of cellular energy metabolism, and mitochondrial energy metabolism defects have been confirmed to be an important potential inducer of CRF (Zhang and Perry 2024)

doi:10.3390/jcm12010145 PubMed PMID: 36614945

This dual-peptide approach has been applied in preclinical and in vitro studies to explore signal integration, temporal hormone release dynamics, and regulatory interactions within the hypothalamic pituitary axis (13)