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doi: 10.1038/nature17184

It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses

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Regular check-ups and lab tests will help ensure that any issues are caught early and managed appropriately

Assavarittirong C, Samborski W, Grygiel-Grniak B

The Pro-Gly-Pro tail is chemically simple but functionally revolutionary: it blocks the carboxypeptidases that would otherwise destroy the peptide and allows enough residence time for nose-to-brain transport, receptor engagement, and downstream gene-expression effects