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Koca R, Armutcu F, Altinyazar HC, Grel A

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48 Should either APAP therapeutic misadventure or intentional overdose be suspected, aggressive antidote intervention with NAC should be of the utmost priority since the benefit of therapy may outweigh the risks of untreated APAP toxicity

Throughout the 14 days of observation after oral administration, there were no deaths and clinical abnormal changes observed in the treated mice, which were dosed at 1500, 3000, 6000 mg of the T1 compound per kilogram of body weight

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These fasted mutants also exhibited physiological changes similar to those observed in wild-type fasted animals, including reduced body size and enhanced motility (Supplementary Fig