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Psychosom Med 72(9):862873 Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y (2014) Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

This initial setup is truly critical

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In 2017, a single-center, randomized, double-blind clinical trial was conducted to evaluate the efficacy of 2 mg once-weekly of exenatide compared with placebo in patients with PD

Even modest weight loss (510%) can yield significant health improvements, so a plateau does not mean the medication isnt working