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The inhibition of cell proliferation and induction of apoptosis in pancreatic ductal adenocarcinoma cells by verrucarin A, a macrocyclic trichothecene, is associated with the inhibition of Akt/NF-B/mTOR prosurvival signaling
Qualifying comorbidities include type 2 diabetes, hypertension, dyslipidemia (abnormal cholesterol levels), and obstructive sleep apnea
To assess changes over time in side effects as rated by the UKU scale, difference scores for side effects were calculated by subtracting the baseline score on the items of the UKU side effects rating scale from the actual scores over time
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