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Smaller, more frequent meals may be better tolerated than large meals
Investigators underlined an increase in heart rate was observed in other GLP-1 receptor agonist studies and changes in heart rate from baseline to week 72 in SURMOUNT-1 indicate the observed heart rate increase may attenuate with continued treatment
While these recommendations are based on observations of thyroid C-cell tumors in rats, it is still unknown whether tirzepatide may also cause thyroid tumors, including medullary thyroid carcinoma, in humans
However, early-stage potency loss (5 to 20%) is invisible