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Increased concentration levels of intracellular zinc by zinc ionophores like pyrithione can efficiently weaken the replication of a variety of RNA viruses (te Velthuis et al
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For instance, supplementation of immature mouse testicular cultures with 5% PRGF was associated with enhanced production of flagellated sperm and increased markers of germ cell proliferation and differentiation, such as PLZF, SYCP3, ACRBP, and Ki67, along with reduced Bax expression (34)
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