Five miRNAs were enriched in liver: hsa-miR-122-5p, hsa-miR-192-5p, hsa-miR-483-5p, hsa-miR-194-5p and hsa-miR-210-3p, whereas other enriched tissue-specific miRNA were as follows: muscle-enriched miRNAs hsa-miR-193 b-5p, hsa-miR-378c and hsa-miR-378a-3p, frontal orbital gyrus-enriched miRNAs miR-125b-3p and hsa-miR-125b-5p, and pancreas-enriched miRNAs hsa-miR-148a-3p and hsa-miR-130b-3p
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However, weight loss through dietary control and regular exercise is considered a fundamental and critical treatment measure, especially in obese or overweight individuals with PCOS
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Finally, the pathophysiological and genetic differences among patients also limit its therapeutic efficacy for RA treatment (95)
