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USA 115 , E6546e6555 (2018)

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A two-stage procedure was pre-specified: in Stage 1 exposure was considered equivalent between the severe RI group and the normal renal function group if the 95% confidence intervals (CIs) for the ratio of AUC (unadjusted) were contained within the pre-specified no effect interval of 0.701.43 (both inclusive)

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