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Under hypoxic conditions, the stabilization of hypoxia-inducible factor-1 (HIF-1) occurs, a process heavily influenced by ROS

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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)