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The same publication also detected an increased abundance of the genus Colidextribacter in patients with impaired intestinal permeability [38]: this taxon has previously been described to play a role in the increase of cellular oxidative stress capacity in a mice model, thus contributing to gut barrier impairment [38]

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IGF-1 exerts negative feedback inhibition of GH and GHRH at the anterior pituitary and hypothalamus, respectively (dashed arrow)

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Leinekugel, X., Medina, I., Khalilov, I., Ben Ari, Y