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Ryan TA, Phillips EO, Collier CL, Jb Robinson A, Routledge D, Wood RE, Assar EA, Tumbarello DA (2020) Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles

But if your goal is simply to support energy levels and overall wellness, L-Carnitine 1500 does that well

doi: 10.1002/dmrr.v26:4 11 HolstJJ

That's hundreds of times more than any patch could realistically deliver through the skin, and berberine's molecular structure isn't ideally suited to transdermal absorption in the first place