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A group of researchers, including oncologists and data scientists, from the University of Florida and Indiana University hypothesized that GLP-1s hold promise in oncology due to their ability to lower glucose, adiposity, insulin resistance, and systemic inflammation factors associated with cancer progression, according to a July 2025 paper published in JAMA

These trials showed that Retatrutides activation of GLP-1, GIP, and glucagon receptors can improve metabolic balance, enhance fat oxidation, and support weight management outcomes in study populations

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Jensterle Sever, M., Kocjan, T., Pfeifer, M., Kravos, N

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Regular monitoring of weight, HbA1c (for diabetes patients), and treatment tolerability is essential to ensure safe and effective use