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The STEP-1 trial demonstrated mean weight loss of 14.9% with weekly semaglutide.[1] The SURMOUNT-1 trial showed 20.9% with tirzepatide.[2] The SELECT cardiovascular outcomes trial revealed a 20% reduction in major adverse cardiovascular events among non-diabetic patients with obesity.[3] These are not supplements
They act on the same GLP-1 receptors but through different chemical structures
Against this backdrop of rising obesity and new pharmacologic strategies, it is critical to note that the majority of patients undergoing orthopedic surgery, particularly joint arthroplasty, meet criteria for obesity (BMI 3039.9) or morbid obesity (BMI 40)
Consult a licensed physician before starting any treatment program
Di Giacomo C, Malfa GA, Tomasello B, Bianchi S, Acquaviva R
B12 Injection Administration Methods Knowing how to give B12 injections is key
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