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doi: 10.3389/fphar.2025.1675015 Received 28 July 2025 Accepted 19 August 2025 Published 01 September 2025 Volume 16 - 2025 Edited by Cristian Sandoval, University of La Frontera, Chile Reviewed by Dan Wu, China Academy of Chinese Medical Sciences, China Jose Javier Ik Yahalcab Zamora Diaz, CMN 20 de noviembre ISSSTE, Mexico Updates Copyright 2025 Zrate, Granados-Soto and Arias-Carrin

Pre-clinical research conducted primarily in animal models informs the hypotheses for its use, but no large randomized controlled trials in humans have confirmed efficacy for any outcome - including gut-lining support, tissue-related processes, or any other claimed mechanism