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Insulin receptor binding and metabolic effects of insulin in human subcutaneous adipose tissue in untreated noninsulin dependent diabetes mellitus

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Structural alterations of the ligand peptides as in GIP/GLP-1 dual-receptor agonists may alter these cellular processes strongly and may explain that an antagonist may activate while an agonist may block receptor signaling (4649)

Receptor binding affinity (EC 50 , Human) = 5

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