Several studies have found that how long B12 remains in the system can depend on underlying factors such as tendencies towards developing certain diseases and lifestyle choices
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Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)
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Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERalpha-mediated signaling pathway
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