Additionally, loss of muscle mass during rapid weight loss can reduce the efficiency of muscle pumps that help return blood from the extremities to the heart, leading to blood stasis, particularly in the legs, which is a risk factor for deep vein thrombosis (DVT)
PMID: 9633054
Whilst there is no confirmed causal link between retatrutide and depression, certain individuals may be more vulnerable to mood changes during any significant pharmacological intervention, particularly one that produces rapid and substantial weight loss
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That weight loss can, in turn, make blood sugar easier to control
