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The reason is how Epithalon is designed to work

In some cases, doctors may recommend hydroxocobalamin injections for the rest of the person's life

Eye cream works better than vitamin K

Clin Cancer Res 17:39934005

EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor

The cornerstone of this approach is achieving precise spatiotemporal control over drug delivery and action, which is fundamentally dependent on guidance from a robust biomarker framework for accurate patient stratification