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PARP1 also has the ability to ADP-ribosylate and deactivate GAPDH, which results in a reduction of GAPDH levels and may, in certain situations, lead to cell death (Maher and Hanneken, 2008)

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How does Ketamine Therapy work Neuroplasticity Ketamine dramatically reorganizes activity in the brain, as if a switch is being flipped on its active circuits