We previously identified that our primary amine-containing degraders were being metabolized into an active aldehyde species that forms a reversible covalent bond with FBXO22 on Cys326 to promote NSD2 degradation 9
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Neumann, P., Lenz, D
Acetylcysteine is indicated as adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in such conditions as: Chronic bronchopulmonary disease (chronic emphysema, emphysema with bronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis and primary amyloidosis of the lung) Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) Pulmonary complications of cystic fibrosis Tracheostomy care Pulmonary complications associated with surgery Use during anesthesia Post-traumatic chest conditions Atelectasis due to mucous obstruction Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization) After proper administration of acetylcysteine, an increased volume of liquified bronchial secretions may occur
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